Mayo Building or Mayo Hall may refer to:
- in India
- Mayo Hall (Bangalore), a historic building
- in the United States
- Mayo Building (Rochester, Minnesota), in Minnesota, a modern complex
- Mayo Clinic Buildings, Rochester, Minnesota, NRHP-listed, including the Plummer Building which is also known as Mayo Clinic Building
- Mayo Building (Tulsa, Oklahoma), listed on the NRHP in Tulsa County, Oklahoma
- Mayo Hall (Commerce, Texas), listed on the U.S. National Register of Historic Places
- Mayo Building (Northfield, Vermont), listed on the NRHP in Washington County, Vermont
See also
- Mayo Hotel, Tulsa, Oklahoma, NRHP-listed
- Mayo House (disambiguation)
